Tetrahedron p. 2181 - 2190 (1987)
Update date:2022-09-26
Topics:
Di Nunno, L.
Scilimati, A.
By reaction of substituted benzonitrile oxides with the enolate ion of acetaldehyde (quantitatively generated by the known cycloreversion of THF in the presence of n-butyllithium) a number of 3-aryl-4,5-dihydro-5-hydroxy-1,2-oxazoles (previously unknown or, in two cases, only synthesized by different procedures) have been isolated in high yields.Treatment of such hydroxy-isoxalines with some common bases allows their conversion in high yields into the corresponding isoxazoles.
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Doi:10.1002/hlca.19870700303
(1987)Doi:10.1016/j.ejmech.2015.05.036
(2015)Doi:10.1016/j.bioorg.2020.103671
(2020)Doi:10.1016/j.tet.2020.131861
(2021)Doi:10.1021/ol900016g
(2009)Doi:10.1021/jo900076r
(2009)
