Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position

DOI: 10.1021/jm00123a010

Source and publish data:

Journal of Medicinal Chemistry p. 569 - 575 (1989)

Update date:2022-09-26

Topics:

Authors:

Marsham Marsham

Chambers

Hayter Hayter

Hughes Hughes

Jackman Jackman

O'Connor

Bishop Bishop

Calvert Calvert

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Article abstract of DOI:10.1021/jm00123a010

The synthesis of 16 new N¹⁰-propargylquinazoline antifolates with methylamino, ethylamino, (2-aminoethyl)amino, [2-(dimethylamino)ethyl]amino, (2-hydroxyethyl)amino, (carboxymethyl)amino, dimethylamino, imidazol-1-yl, methoxy, ethoxy, phenoxy,

Full text of DOI:10.1021/jm00123a010

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