B(C6F5)3-Catalyzed α-Deuteration of Bioactive Carbonyl Compounds with D2O

DOI: 10.1002/adsc.201901419

Source and publish data:

Advanced Synthesis and Catalysis p. 360 - 364 (2020)

Update date:2022-08-04

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Authors:

Chang, Yejin

Myers, Tanner

Wasa, Masayuki

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Article abstract of DOI:10.1002/adsc.201901419

An efficient deuteration process of α-C?H bonds in various carbonyl-based pharmaceutical compounds has been developed. Catalytic reactions are initiated by the action of Lewis acidic B(C₆F₅)₃ and D₂O, converting

Full text of DOI:10.1002/adsc.201901419

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