AMINATION OF THE PYRIDINIUM CATIONS IN BETAINES. SYNTHESIS OF SUBSTITUTED PYRIMIDO-1'-AZAQUINOLIZINE AND ITS DIHYDRO ANALOGS

Article abstract of DOI:10.1007/BF00476389

The pyridinium cations within betaines can be aminated under mild conditions with aqueous ammonia, ultimately undergoing cyclization to a new tricyclic system: 4-substituted-3,5-dioxopyrimido<5,6-c>-1'-azaquinolizine.Intermediates in the reaction are 4-substituted-3,5-dioxo-2,2-dihydropyrimido<5,6-c>-6H-1'-quinolizines.