Synthesis of the Combined Centre- and Right-hand Section of the Antitumour Agent CC-1065

Article abstract of DOI:10.1016/S0040-4039(00)96312-3

The complete centre-and right-hand section of the anti-tumour antibiotic CC-1065, known as PDE-I dimer (3), has been synthesised by coupling the pyrroloindole (6) and pyrroloindoline (5), followed by functional group transformations; the synthetic PDE-I dimer (3) was identical to material obtained from natural sources, and since natural PDE-I dimer has been converted into CC-1065, this work constitutes a formal total synthesis of the antibiotic.