Optically Pure (4aS)-(+)- or (4aR)-(-)-1,4a-Dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione and Its Use in the Synthesis of an Inhibitor of Steroid Biosynthesis

Article abstract of DOI:10.1021/jo00245a033

Synthesis of the optically pure enone 1 is described.Reestimation of the optical purity and reexamination of the absolute stereochemistry of 1 have been studied.Usefulness of the enone 1 is demonstrated by a five-step synthesis of (-)-3, an inhibitor of steroid biosynthesis.