Bioorganic and Medicinal Chemistry Letters p. 1380 - 1383 (2006)
Update date:2022-08-05
Topics:
Bian, Xiaoli
He, Langchong
Yang, Guangde
Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of β-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.
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