Substituted Benzamides. 1. Potential Nondopaminergic Antagoinists of Chemotherapy-Induced Nausea and Emesis

DOI: 10.1021/jm00403a011

Source and publish data:

Journal of Medicinal Chemistry p. 1548 - 1557 (1988)

Update date:2022-07-29

Topics:

Authors:

Monkovic, Ivo

Wllner, David

Adam, Michael A.

Brown, Myron

Crenshaw, R. R.

et al. et al.

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Article abstract of DOI:10.1021/jm00403a011

A series of new substituted benzamides has been synthesized and evaluated for dopamine antagonist activity and for antagonism of cisplatin-induced emesis in the dog and in the ferret.It was found that modification of the 2-methoxy substituent of metoclopr

Full text of DOI:10.1021/jm00403a011

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