Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase

DOI: 10.1016/j.bmcl.2009.06.058

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4724 - 4728 (2009)

Update date:2022-07-30

Topics:

Authors:

Wurz, Ryan P.

Pettus, Liping H.

Xu, Shimin

Henkle, Bradley

Sherman, Lisa

Plant, Matthew

Miner, Kent

McBride, Helen

Wong, Lu Min

Saris, Christiaan J.M.

Lee, Matthew R.

Chmait, Samer

Mohr, Christopher

Hsieh, Faye

Tasker, Andrew S.

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Article abstract of DOI:10.1016/j.bmcl.2009.06.058

A novel class of fused pyrazole-derived inhibitors of p38α mitogen-activated protein kinase (MAPK) is disclosed. These inhibitors were evaluated for their ability to inhibit the p38α enzyme, the secretion of TNFα in a LPS-challenged THP1 cell line and TNF

Full text of DOI:10.1016/j.bmcl.2009.06.058

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