A convenient synthesis of ethyl 3,3,3,-trifluoropropanoate and its 2-bromo derivative

Article abstract of DOI:10.1016/S0022-1139(00)82015-1

Ethyl 3,3,3-trifluoropropanoate and ethyl 2-bromo-3,3,3-trifluoropropanoate have been synthesized. A common intermediate ethyl 3-chloro (or 3-bromo)-3,3-difluoropropanoate is involved in the two syntheses. These esters are obtained by oxidation of the corresponding acetals resulting from the radical addition of CF₂BrCl or CF₂Br₂ to ethyl vinyl ether.