4- AND 5-HYDROXYLAMINOTHIAZOLIDINE-2-THIONES. REARRANGEMENT OF THE CARBAMOYL DERIVATIVES TO 4- AND 5-UREIDOTHIAZOLIDIN-2-ONES

Article abstract of DOI:10.1007/BF00472264

The carbamoylation of 4- and 5-hydroxylaminothiazolidine-2-thiones by methyl and 3,4-dichlorophenyl isocyanates leads to the corresponding hydroxyureas, which rearrange to 4- and 5-ureidothiazolidin-2-ones on heating in the presence of a base.Under these conditions, the hydroxyurea based on 5-hydroxylaminothiazolidin-2-one is converted to 5-ureidooxazolidin-2-one.