CONSTRUCTION OF CHIRAL QUARTERNARY CARBON CENTERS USING 3-SUBSTITUTED 5-TRIMETHYLSILYL-2-CYCLOHEXENONES: SYNTHESIS OF (+)-α-CUPARENONE

Article abstract of DOI:10.1016/S0040-4039(00)80086-6

1,4-Addition of Grignard reagents to 3-substituted 5-trimethylsilyl-2-cyclohexenones proceeded in a highly diastereoselective manner.By utilizing the reaction, (+)-α-cuparenone was synthesized starting from enantiomerically pure 3-p-tolylthio-5-(trimethyl