ASYMMETRIC REDUCTION OF Z-3-CHLORO-3-ALKEN-2-ONES WITH FERMENTING BAKER'S YEAST

DOI: 10.1016/S0040-4039(00)85052-2

Source and publish data:

Tetrahedron Letters p. 4737 - 4740 (1986)

Update date:2022-08-04

Topics:

Authors:

Utaka, Masanori

Konishi, Satoshi

Takeda, Akira

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Article abstract of DOI:10.1016/S0040-4039(00)85052-2

Using fermenting baker's yeast, Z-RCH=CClCOCH3 (R=C2H5, n-C5H11, n-C8H17) was reduced initially to (S)-RCH2C^*HClCOCH3 in 44-84percent ee, which was further reduced to RCH2C^*HClC^*HOHCH3 in >98percent ee with the syn(2R,3S)/anti(2S,3R) ratios of 2.6-18.3.

Full text of DOI:10.1016/S0040-4039(00)85052-2

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