Structure-activity relationships in prazosin-related compounds. Effect of replacing a piperazine ring with an alkanediamine moiety on α1-adrenoreceptor blocking activity

Article abstract of DOI:10.1021/jm00121a011

Several prazosin-related compounds were synthesized in which the piperazine ring of prazosin (1) was replaced by an alkanediamine chain and were evaluated for their blocking activity on α₁- and α₂-adrenoreceptors in isolated rat vas