Structure-activity relationships in prazosin-related compounds. Effect of replacing a piperazine ring with an alkanediamine moiety on α1-adrenoreceptor blocking activity

DOI: 10.1021/jm00121a011

Source and publish data:

Journal of Medicinal Chemistry p. 50 - 55 (1989)

Update date:2022-08-05

Topics:

Authors:

Giardina

Brasili Brasili

Gregori Gregori

Massi Massi

Picchio Picchio

Quaglia Quaglia

Melchiorre

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Article abstract of DOI:10.1021/jm00121a011

Several prazosin-related compounds were synthesized in which the piperazine ring of prazosin (1) was replaced by an alkanediamine chain and were evaluated for their blocking activity on α₁- and α₂-adrenoreceptors in isolated rat vas

Full text of DOI:10.1021/jm00121a011

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