CHIRAL SYNTHESIS OF ISOCARBACYCLIN -9-METHANO-Δ6-PGI1> INTERMEDIATE VIA RHODIUM-CATALYZED INTRAMOLECULAR C-H INSERTION REACTION

Article abstract of DOI:10.1016/S0040-4039(00)95800-3

A key intermediate for the synthesis of isocarbacyclin, a promising therapeutic agent for cardiovascular and circulatory disorders, has been synthesized from (R)-(+)-methyl 2-oxo-1-cyclopentaneacetate by employing rhodium(II)-catalyzed intramolecular C-H insertion reaction of α-diazo β-keto ester as a key step.