Enantioselective Hydrolysis of Dialkyl 3-Monosubstituted Glutarates with Pig Liver Esterase: Structure-Optical Purity Relationships

DOI: 10.1016/S0040-4039(00)80391-3

Source and publish data:

Tetrahedron Letters p. 3951 - 3954 (1988)

Update date:2022-07-30

Topics:

Authors:

Nakada, Masahisa

Kobayashi, Susumu

Ohno, Masaji

Iwasaki, Shigeo

Okuda, Shigenobu

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Article abstract of DOI:10.1016/S0040-4039(00)80391-3

Dialkyl 3-monosubstituted glutarates are subjected to hydrolysis with pig liver esterase to afford the corresponding chiral half-esters.Synnthetically useful half-esters of higher optical purity are obtained from the prochiral substrates of more hydrophob

Full text of DOI:10.1016/S0040-4039(00)80391-3

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