Carbonylative coupling of an amino acid-derived organozine reagent with functionalized aryl iodides: Synthesis of kynurenine

DOI: 10.1039/c39950002207

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Journal of the Chemical Society. Chemical communications p. 2207 - 2208 (1995)

Update date:2022-08-03

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Authors:

Jackson Jackson

Turner Turner

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Article abstract of DOI:10.1039/c39950002207

The utility of the palladium(o) catalysed reaction of the serine-derived organozinc reagent 6 with functionalized aryl iodides, under a carbon monoxide atmosphere, to give protected 4-aryl-4-oxo α-amino acids 8 is illustrated by a short synthesis of L-kynurenine.

Full text of DOI:10.1039/c39950002207

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