Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-Selective Androgen Receptor Modulators (SARMs)

DOI: 10.1021/jm900880r

Source and publish data:

Journal of Medicinal Chemistry p. 4578 - 4581 (2009)

Update date:2022-07-29

Topics:

Authors:

Mitchell, Helen J.

Dankulich, William P.

Hartman, George D.

Prueksaritanont, Thomayant

Schmidt, Azriel

Vogel, Robert L.

Bai, Chang

McElwee-Witmer, Sheila

Zhang, Hai Z.

Chen, Fang

Leu, Chih-Tai

Kimmel, Donald B.

Ray, William J.

Nantermet, Pascale

Gentile, Michael A.

Duggan, Mark E.

Meissner, Robert S.

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Article abstract of DOI:10.1021/jm900880r

A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potenthARbinding and agonist activity, low virilizing potential, and good pharmacokinetic profiles in dogs

Full text of DOI:10.1021/jm900880r

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Product name:16-[(3,5-difluorophenyl)methylidene]-17β-hydroxy-4-methyl-4-aza-5α-androst-1-en-3-one

Cas No:1179423-92-7

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