CHLORO- AND IODOTRIMETHYLSILANE-ACTIVATED ADDITIONS OF ORGANOCOPPER COMPOUNDS TO ENONES AND ENOATES

Article abstract of DOI:10.1016/S0040-4020(01)90348-5

Organocopper compounds add to enones and enoates in the presence of chloromethylsilane in ether giving the conjugate adducts in preparatively usefu yields via the silyl enol ethers.Presence of lithium iodide is important and excess of chlorotrimethylsilane accelerates the reactions.The combination of organocopper compound, iodotrimethylsilane and dimethyl sulfide gave faster reactions and very high yields, particularly in dichloromethane, where the reaction mixtures gradually became homogeneous.