Tetrahedron Letters p. 4541 - 4544 (2009)
Update date:2022-07-29
Topics:
Andrus, Merritt B.
Harper, Kaid C.
Christiansen, Michael A.
Binkley, Meisha A.
Phenethyl arylacetates are alkylated under phase-transfer conditions with cinchona catalysts with alkyl halides in high yield with excellent enantioselectivity (84-99% ee) following recrystallization. Cinchonidine (CD) derived catalyst gave the (R)-product and cinchonine (CN) catalyst produced the (S)-product. The phenethyl (PE) ester group is removed, using ammonium formate and catalytic Pd/C, to give alkylated carboxylic acid products in high selectivity. The utility of the approach is demonstrated by a direct synthesis of (S)-naproxen.
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