Antitumor and antiviral activity of synthetic α- and β-ribonucleosides of certain substituted pyrimido[5,4-d]pyrimidines: a new synthetic strategy for exocyclic aminonucleosides

Article abstract of DOI:10.1021/jm00123a022

A novel and direct synthesis of the antiviral and antitumor agent 4-amino-8-(β-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine (ARPP, 8) and its α-anomer (11) has been developed. Treatment of 2,4,6,8-tetrachloro-pyrimido[5,4-d]pyrimidine (1) with 2,3-O-iso