A mild, highly efficient, and chemoselective deprotection of trityl ethers of carbohydrates and nucleosides using iodine monobromide

Article abstract of DOI:10.1055/s-0029-1217356

Iodine monobromide in dichloromethane-methanol or acetonitrile constitutes an effective reagent for the deprotection of O-trityl and O-dimethoxytrityl ethers of carbohydrates and nucleosides. Acid-labile functionalities (acetals, O-p-methoxybenzyl ethers, etc.) as well as base-labile groups (esters and amides) are stable under these conditions; and the method has been found to be superior to the hitherto known literature methods. Georg Thieme Verlag Stuttgart.