A HIGHLY EFFECTIVE ASYMMETRIC SYNTHESIS OF α-HYDROXY ACIDS BY ALKYLATION OF CHIRAL N-(BENZYLOXYACETYL)-TRANS-2,5-BIS(METHOXYMETHOXYMETHYL)PYRROLIDINE

DOI: 10.1016/S0040-4039(00)94889-5

Source and publish data:

Tetrahedron Letters p. 1343 - 1344 (1985)

Update date:2022-07-29

Topics:

Authors:

Enomoto, Masayuki

Ito, Yoshio

Katsuki, Tsutomu

Yamaguchi, Masaru

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Article abstract of DOI:10.1016/S0040-4039(00)94889-5

Alkylation of lithiated N-(benzyloxyacetyl)-trans-2,5-bis(methoxymethoxymethyl)-pyrrolidine proceeded with high stereoselectivity (>96percent de) and subsequent transformations of the alkylated products gave synthetically useful α-benzyloxy acids or α-hydroxy acids of high enantiomeric purity.

Full text of DOI:10.1016/S0040-4039(00)94889-5

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