Comparison of the biological effects of selected 5,8-dideazafolate analogues with their-2-desamino counterparts

Article abstract of DOI:10.1021/jm00124a019

Three new 5,8-dideaza analogues of folic acid devoid of an amino group at position 2 have been prepared by using synthetic routes patterned after earlier methodologies. They were 2-desamino-5,8-dideazaisofolic acid, 2b, 2-desamino-10-thia-5,8-dideazafolic