Phase-vanishing method with gas evolution and its application to organic synthesis

Article abstract of DOI:10.1016/j.tetlet.2015.12.115

Using a phase-vanishing (PV) system, hydrogen, oxygen, and hydrogen sulfide generated in situ from CaH₂, KO₂, and P₂S₅, respectively, were directly reacted with substances in the organic phase to afford the desired products. The selective synthesis of sulfides and disulfides was achieved with the evolution of H₂S gas via tuning the bases used in the PV method. Using this PV system, reactions with hazardous gaseous reagents can be carried out easily and safely in a common test tube.