Synthesis of 3-Substituted Ethyl 4,4,4-Trichloro-2-cyanobutanoates via Michael Addition to Ethyl 4,4,4-Trichloro-2-cyano-2-butenoate

DOI: 10.1055/s-1988-27652

Source and publish data:

Synthesis p. 611 - 614 (1988)

Update date:2022-08-03

Topics:

Authors:

Gaudemar-Bardone, Francoise

Mladenova, Margarita

Gaudemar, Marcel

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Article abstract of DOI:10.1055/s-1988-27652

The title compounds 2 and 3 are easily synthesized in good to excellent yields and high stereoselectivity by addition of various nucleophiles, such as organometallic reagents, alcohols, thiols, phosphorus compounds and aniline, to ethyl 4,4,4-trichloro-2-cyano-2-butenoate.

Full text of DOI:10.1055/s-1988-27652

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