The total synthesis of avermectin A(1a)

DOI: 10.1021/ja00190a034

Source and publish data:

Journal of the American Chemical Society p. 2967 - 2980 (1989)

Update date:2022-08-02

Topics: Total synthesis Purification Reaction Conditions Spectroscopic Analysis

Authors:

Danishefsky

Armistead

Wincott Wincott

Selnick Selnick

Hungate Hungate

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Article abstract of DOI:10.1021/ja00190a034

Key fragments for the total synthesis of the title compound were elaborated from D-ribose and D-glucose and coupled through a crossed aldol dehydration maneuver (33 + 44→46). An intramolecular variant of the Nozaki reaction (47→48) led to the all-critical

Full text of DOI:10.1021/ja00190a034

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