The total synthesis of avermectin A(1a)

DOI: 10.1021/ja00190a034

Source and publish data:

Journal of the American Chemical Society p. 2967 - 2980 (1989)

Update date:2022-08-02

Topics: Total synthesis Purification Reaction Conditions Spectroscopic Analysis

Authors:

Danishefsky

Armistead

Wincott Wincott

Selnick Selnick

Hungate Hungate

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/ja00190a034

Key fragments for the total synthesis of the title compound were elaborated from D-ribose and D-glucose and coupled through a crossed aldol dehydration maneuver (33 + 44→46). An intramolecular variant of the Nozaki reaction (47→48) led to the all-critical

Full text of DOI:10.1021/ja00190a034

Products guided by the article

Product name:Acetic acid (2S,3S,4R,5R,6S)-5-iodo-4-methoxy-6-((2S,3S,4S,6S)-4-methoxy-2-methyl-6-phenylsulfanyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-3-yl ester

Cas No:119616-49-8

R&D Labs maybe for 119616-49-8

Hangzhou Mole's Science & Technology Co.,Ltd.(expird)

Contact:+86-571-56880228

Address:15F Guodu development Building, NO.182 Zhaohui Road
Jiangsu Fengshan Group Co., Ltd.

Contact:86-25-86558671

Address:1903,Central International Mansion 105-6 North Zhongshan Road, Nanjing, China
Hubei Onward Bio-Development Co., Ltd.

Contact:+86-718-8417012

Address:No.517,Shizhou Avenue,Enshi City,Hubei Province,China,445002
Shandong Xiangde Biotechnology Co., Ltd

Contact:+86 -15066639877

Address:Sanba street
SHANXI JINJIN CHEMICAL INDUSTRIAL CO.,LTD

website:http://www.jinjingroup.com

Contact:86-574-13989382828

Address:Economic And Technological Development Zone,Hejin?City,Shanxi Province?,China

Relevant to this article

Tetraaryl-methane analogues in group 14 - 4. Ph4-nM(p-Tol)n (n=0-4, M=Si, Ge, Sn, Pb). Synthesis, structuraland spectroscopic data, and semiempirical calculations: mutual interaction of tetrahedral σ-orbitals (symmetry and electronegativity) and delocalized σ*-lumos

Doi:10.1016/0277-5387(95)00069-5
(1995)
Regioselective Formation of Enol Esters from the Ruthenium-Catalyzed Markovnikov Addition of Carboxylic Acids to Alkynes

Doi:10.1021/acs.joc.5b02293
(2016)
B(C₆F₅)₃-Catalyzed reduction of ketones and imines using silicon-stereogenic silanes: Stereoinduction by single-point binding

Doi:10.1002/ejoc.200900796
(2009)
Efficient one-step synthesis of benzazoles in aqueous media

Doi:10.1002/ejoc.200900740
(2009)
Bifunctional Thiourea-Catalyzed Stereoablative Retro-Sulfa-Michael Reaction: Concise and Diastereoselective Access to Chiral 2,4-Diarylthietanes

Doi:10.1055/s-0036-1588612
(2017)
Selective cross-linking of interacting proteins using self-labeling tags

Doi:10.1021/ja907818q
(2009)

Article Doi