The total synthesis of avermectin A(1a)

DOI: 10.1021/ja00190a034

Source and publish data:

Journal of the American Chemical Society p. 2967 - 2980 (1989)

Update date:2022-08-02

Topics: Total synthesis Purification Reaction Conditions Spectroscopic Analysis

Authors:

Danishefsky

Armistead

Wincott Wincott

Selnick Selnick

Hungate Hungate

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/ja00190a034

Key fragments for the total synthesis of the title compound were elaborated from D-ribose and D-glucose and coupled through a crossed aldol dehydration maneuver (33 + 44→46). An intramolecular variant of the Nozaki reaction (47→48) led to the all-critical

Full text of DOI:10.1021/ja00190a034

Products guided by the article

Product name:Acetic acid (2S,3S,4R,5R,6S)-5-iodo-4-methoxy-6-((2S,3S,4S,6S)-4-methoxy-2-methyl-6-phenylsulfanyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-3-yl ester

Cas No:119616-49-8

R&D Labs maybe for 119616-49-8

Shanghai Topchem Co., LTD

website:http://www.shtopchem.com/

Contact:0086-0576-87776998

Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district
Changsha Botaniex Inc.

Contact:(86) 731 88718666

Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
FREEBARQUE DEVELOPMENT GROUP LIMITED

Contact:+86(0)10-5109 5335 or 5109 5345

Address:Room602,Block1-B,LINGDI OFFICE,NO.13 BEIYUAN ROAD
Yixing Bluwat Chemicals Co., Ltd.

Contact:+86 510 87821568

Address:Yongan Road, Yixing Chemical Industrial Park, Yixing, Jiangsu, China
Tianjin Anda North Industrial & Business Co.Ltd.

Contact:86-22-24999306

Address:No.11 Erwei Road,Dongli Development Area,Tianjin,China

Relevant to this article

Tetraaryl-methane analogues in group 14 - 4. Ph4-nM(p-Tol)n (n=0-4, M=Si, Ge, Sn, Pb). Synthesis, structuraland spectroscopic data, and semiempirical calculations: mutual interaction of tetrahedral σ-orbitals (symmetry and electronegativity) and delocalized σ*-lumos

Doi:10.1016/0277-5387(95)00069-5
(1995)
Regioselective Formation of Enol Esters from the Ruthenium-Catalyzed Markovnikov Addition of Carboxylic Acids to Alkynes

Doi:10.1021/acs.joc.5b02293
(2016)
B(C₆F₅)₃-Catalyzed reduction of ketones and imines using silicon-stereogenic silanes: Stereoinduction by single-point binding

Doi:10.1002/ejoc.200900796
(2009)
Efficient one-step synthesis of benzazoles in aqueous media

Doi:10.1002/ejoc.200900740
(2009)
Bifunctional Thiourea-Catalyzed Stereoablative Retro-Sulfa-Michael Reaction: Concise and Diastereoselective Access to Chiral 2,4-Diarylthietanes

Doi:10.1055/s-0036-1588612
(2017)
Selective cross-linking of interacting proteins using self-labeling tags

Doi:10.1021/ja907818q
(2009)

Article Doi