THE FRIEDEL-CRAFTS ACYLATION OF ETHYL PYRROLE-2-CARBOXYLATE. SCOPE, LIMITATIONS, AND APPLICATION TO SYNTHESIS OF 7-SUBSTITUTED INDOLES

DOI: 10.3987/COM-88-4616

Source and publish data:

Heterocycles p. 1855 - 1860 (1988)

Update date:2022-07-30

Topics:

Authors:

Murakami, Yasuoki

Tani, Masanobu

Ariyasu, Takahiro

Nishiyama, Chika

Watanabe, Toshiko

Yokoyama, Yuusaku

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Article abstract of DOI:10.3987/COM-88-4616

The Friedel-Crafts acylation of ethyl pyrrole-2-carboxylate (3) was studied under a variety of conditions using various Lewis acids and acyl chlorides.The acylation with some Lewis acids such as BF3*OEt2 gave a mixture of 4- and 5-acyl derivatives (5 and

Full text of DOI:10.3987/COM-88-4616

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