Bioorganic and Medicinal Chemistry Letters p. 1169 - 1173 (2012)
Update date:2022-08-03
Topics:
McCauley Jr., John P.
Dantzman, Cathy L.
King, Megan M.
Ernst, Glen E.
Wang, Xia
Brush, Kelly
Palmer, William E.
Frietze, William
Andisik, Donald W.
Hoesch, Valerie
Doring, Kenneth
Hulsizer, James
Bui, Khanh H.
Liu, Jay
Hudzik, Thomas J.
Wesolowski, Steven S.
A novel series of piperazine derivatives exhibits sub-nanomolar binding and enhanced subtype selectivity as δ-opioid agonists. The synthesis and SAR are described as well as the application of computational models to improve in vitro ADME and safety prope
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