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Z. Sun et al.
Paper
Synthesis
2-(4-methoxyphenyl)-2-phenylisoindolin-1-one (4b)
Compound 4b was purified by TLC (petroleum ether/acetone, 10:1).
Yield: 40% (63 mg); yellow oil.
1H NMR (400 MHz, CDCl3): = 7.94 (d, J = 7.1 Hz, 1 H), 7.57–7.52 (m, 2
H), 7.49 (t, J = 7.5 Hz, 2 H), 7.20–7.25 (m, 3 H), 7.15–7.04 (m, 2 H), 6.78
(d, J = 7.6 Hz, 2 H), 5.98 (s, 1 H), 3.72 (s, 3 H).
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13C NMR (101 MHz, CDCl3): = 167.3, 134.4, 131.7, 130.0, 129.7,
129.1, 128.8, 128.8, 128.1, 126.6, 123.7, 113.8, 113.7, 113.4, 55.2, 51.6.
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Jiao, N. Acc. Chem. Res. 2017, 50, 1640. (b) Yi, H.; Zhang, G.;
Wang, H.; Huang, Z.; Wang, J.; Singh, A. K.; Lei, A. Chem. Rev.
2017, 117, 9016. (c) Wang, H.; Gao, X.; Lv, Z.; Abdelilah, T.; Lei,
A. Chem. Rev. 2019, 119, 6769. (d) Shang, R.; Ilies, L.; Nakamura,
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HRMS (ESI): m/z calcd for C21H17NO2 + Na+: 338.1157; found:
338.1159.
Funding Information
This work was financially supported by National Natural Science
Foundation of China (NNSFC, No. 21562038) for supporting our re-
search. The authors also thank Natural Science Foundation of Jiangsu
(8) Recent progress of C–H bond functionalization: (a) Yang, X.;
Zhu, Y.; Xie, Z.; Li, Y.; Zhang, Y. Org. Lett. 2020, 22, 1638.
(b) Anand, D.; Sun, Z.; Zhou, L. Org. Lett. 2020, 22, 2371.
(c) Zhao, X.; Liang, S.; Fan, X.; Yang, T.; Yu, W. Org. Lett. 2019, 21,
1559. (d) Yu, Z.; Zhang, Y.; Tang, J.; Zhang, L.; Liu, Q.; Li, Q.; Gao,
G.; You, J. ACS Catal. 2020, 10, 203. (e) Roque, J. B.; Kuroda, Y.;
Jurczyk, J.; Xu, L.-P.; Ham, J. S.; Göttemann, L. T.; Roberts, C. A.;
Adpressa, D.; Saurí, J.; Joyce, L. A.; Musaev, D. G.; Yeung, C. S.;
Sarpong, R. ACS Catal. 2020, 10, 2929. (f) Liu, S.; Shen, T.; Luo, Z.;
Liu, Z.-Q. Chem. Commun. 2019, 55, 4027. (g) Wu, J.; Zhou, Y.;
Zhou, Y.; Chiang, C.-W.; Lei, A. ACS Catal. 2017, 7, 8320.
(h) Prusinowski, A. F.; Twumasi, R. K.; Wappes, E. A.; Nagib, D. A.
J. Am. Chem. Soc. 2020, 142, 5429. (i) Tang, S.; Zeng, L.; Lei, A.
J. Am. Chem. Soc. 2018, 140, 13128. (j) Wang, H.; Zhang, D.;
Bolm, C. Angew. Chem. Int. Ed. 2018, 57, 5863. (k) Hu, X.-Q.;
Chen, J.-R.; Xiao, W.-J. Angew. Chem. Int. Ed. 2017, 56, 1960.
(l) Wang, H.; Li, Y.; Lu, Q.; Yu, M.; Bai, X.; Wang, S.; Cong, H.;
Zhang, H.; Lei, A. ACS Catal. 2019, 9, 1888. (m) Yuan, P.-F.;
Zhang, Q.-B.; Jin, X.-L.; Lei, W.-L.; Wu, L.-Z.; Liu, Q. Green Chem.
2018, 20, 5464.
Province (BK20161328) for financial support.
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