Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist

DOI: 10.1016/j.bmc.2016.05.048

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Bioorganic and Medicinal Chemistry p. 3436 - 3446 (2016)

Update date:2022-08-03

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Authors:

Koura, Minoru

Yamaguchi, Yuki

Kurobuchi, Sayaka

Sumida, Hisashi

Watanabe, Yuichiro

Enomoto, Takashi

Matsuda, Takayuki

Okuda, Ayumu

Koshizawa, Tomoaki

Matsumoto, Yuki

Shibuya, Kimiyuki

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Article abstract of DOI:10.1016/j.bmc.2016.05.048

Our research found that the 2-hydroxyacetophenone derivative is an outstanding linker between the 1,1-bistrifluoromethylcarbinol moiety and the imidazolidine-2,4-dione moiety to enhance the potency and β-selectivity of liver X receptor (LXR) agonist in ou

Full text of DOI:10.1016/j.bmc.2016.05.048

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