
Tetrahedron p. 181 - 190 (1989)
Update date:2022-09-26
Topics:
Banaigs, B.
Jeanty, G.
Francisco, C.
Jouin, P.
Poncet, J.
et al.
A comparative study of isodidemnine-1 and didemnin B is presented using spectroscopic methods, partial degradation and partial synthesis.This leads to the conclusion of the presence of a single depsipeptide, namely didemnin B, with (3S,4R,5S)isostatine instead of the previous statine residue.An attempt to determine the whole conformation in solution of didemnin B by using 2D-NMR is also described.
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