A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: Synthesis and structure-activity relationships

DOI: 10.1016/j.bmcl.2012.12.061

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1456 - 1461 (2013)

Update date:2022-09-26

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Authors:

Van Orden, Lori Jean

Van Dyke, Priscilla M.

Saito, D. Roland

Church, Timothy J.

Chang, Ray

Smith, Jacqueline A.M.

Martin, William J.

Jaw-Tsai, Sarah

Stangeland, Eric L.

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Article abstract of DOI:10.1016/j.bmcl.2012.12.061

A series of 3-(phenoxy-phenyl-methyl)-pyrrolidine analogues were discovered to be potent and balanced norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors. Several of these compounds were identified to have suitable in vitro p

Full text of DOI:10.1016/j.bmcl.2012.12.061

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