Nucleic acid related compounds. 57. Synthesis, X-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides

DOI: 10.1021/jm00128a017

Source and publish data:

Journal of Medicinal Chemistry p. 1763 - 1768 (1989)

Update date:2022-07-30

Topics:

Authors:

Robins Robins

Wood Wood

Dalley Dalley

Herdewijn

Balzarini

De Clercq

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Article abstract of DOI:10.1021/jm00128a017

Trimethylsilyl triflate-catalyzed transfer glycosylation of 2,6-diacetamidopurine (2) with 3'-azido-3'-deoxythymidine (AZT, 1) as donor followed by deprotection gave 2,6-diamino-9-(3-azido-2,3-dideoxy-α- and -β-D-erythro-pentofuranosyl)purines (3 and 4) i

Full text of DOI:10.1021/jm00128a017

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