An Efficient Synthesis of Novel α-Diketone and α-Keto Ester Derivatives of N-Protected Amino Acids and Peptides

Article abstract of DOI:10.1021/jo00277a031

A novel synthetic approach to α-diketone and α-keto ester derivatives of N-protected amino acids and peptides via a common intermediate is described.Conversion of the carboxyl group of N-protected amino acids and peptides into an α-keto vinyl ether functi