Journal of Medicinal Chemistry p. 2058 - 2062 (1989)
Update date:2022-08-04
Topics:
Brewer, Malcolm D.
Burgess, Malcolm N.
Dorgan, Roderick J. J.
Elliott, Richard L.
Mamalis, Patrick
et al.
A series of 1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine derivatives was prepared and the cestocidal activity of the compounds evaluated in an in vitro Taenia crassiceps screen.Many of these derivatives proved to be highly active, and 2-(cyclohexylcarbonyl)-4-oxo-1,2,3,4,6,7,8,12b-octahydropyrazino<2,1-a><2>benzazepine, epsiprantel (BAN) (22), was selected for further development.The structure-activity relationships are discussed.
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