First synthesis of optically pure α-amino amine as asymmetric amino transfer reagent and its use in asymmetric Mannich reaction

Article abstract of DOI:10.1016/S0040-4039(00)73085-1

An optically pure α-amino amine was first synthesized from L-lysine utilizing anodic oxidation as a key step, and its usefulness was exemplified by the asymmetric Mannich reaction to give optically active β-amino acid esters.