Preparation and Crystal Structure of New Gold(I) Complexes Linked to Pyrimidines

Article abstract of DOI:10.1246/bcsj.62.1078

Two new gold(I) complexes linked to pyrimidines, (5-fluoro-2'-deoxyuridinato-N³)(triphenylphosphine)-gold(I) (I) and <5-fluoro-1-(twtrahydro-2-furanyl)-2,4(1H,3H)-pyridinedionato-N³>(triphenylphosphine)gold(I) (2) were synthesized and characterized by 31P, 1H NMR and IR spectra.The structure of 2 was determined by an X-ray diffraction method.A linear, two-coordination around gold(I) has been shown.In order to estimate the possible alteration of 1 and 2 in vivo, several factors such as the effect of pH, and reactions with thiol, thiophenol, and imidazole were examined.