Inhibition studies of some serine and thiol proteinases by new leupeptin analogues

Article abstract of DOI:10.1021/jm00060a016

Fifteen tripeptide analogues of leupeptin containing either a C-terminal argininal or lysinal were synthesized. The synthetic analogues were tested, using spectrophotometric assay techniques, as inhibitors of trypsin, kallikrein, thrombin, plasmin, and ca