Bioorganic and Medicinal Chemistry Letters p. 2533 - 2537 (2010)
Update date:2022-08-05
Topics:
Kuduk, Scott D.
Di Marco, Christina N.
Chang, Ronald K.
Ray, William J.
Ma, Lei
Wittmann, Marion
Seager, Matthew A.
Koeplinger, Kenneth A.
Thompson, Charles D.
Hartman, George D.
Bilodeau, Mark T.
The phenyl ring in a series of quinolone carboxylic acid M1 positive allosteric modulators was replaced with a variety of heterocycles in order to reduce protein plasma binding and enhance CNS exposure.
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