Secondary β-Aminobenzamide and Heteroatom Directed Lithiation in the Synthesis of 5,6-Dimethoxyanthanilamides and Related Compounds

DOI: 10.1021/jo00280a020

Source and publish data:

Journal of Organic Chemistry p. 4549 - 4553 (1989)

Update date:2022-07-29

Topics: Synthesis Compound Benzene Nitrogen Experimental Lithium

Authors:

Bengtsson, Stefan

Hoegberg, Thomas

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Article abstract of DOI:10.1021/jo00280a020

Directed ortho-lithiation strategies have been applied in the synthesis of the dopamine D-2 antagonist (S)-6-amino-5-bromo-2,3-dimethoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide (NCQ 318).The secondary β-amino side chain was found to be a powerful orth

Full text of DOI:10.1021/jo00280a020

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