Journal of Organic Chemistry p. 4549 - 4553 (1989)
Update date:2022-07-29
Topics: Synthesis Compound Benzene Nitrogen Experimental Lithium
Bengtsson, Stefan
Hoegberg, Thomas
Directed ortho-lithiation strategies have been applied in the synthesis of the dopamine D-2 antagonist (S)-6-amino-5-bromo-2,3-dimethoxy-N-<(1-ethyl-2-pyrrolidinyl)methyl>benzamide (NCQ 318).The secondary β-amino side chain was found to be a powerful orth
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