Molecules p. 4423 - 4438 (2010)
Update date:2022-08-03
Topics:
Dahlgren, Markus K.
Oeberg, Christopher T.
Wallin, Erika A.
Janson, Paer G.
Elofsson, Mikael
Salicylidene acylhydrazides are inhibitors of type III secretion in several Gramnegative pathogens. To further develop the salicylidene acylhydrazides, scaffold hopping was applied to replace the core fragment of the compounds. The novel 2-(2-aminopyrimidine)-2,2-difluoroethanol scaffold was identified as a possible analog to the salicylidene acylhydrazide core structure. The synthesis of a library of 2-(2-aminopyrimidine)-2,2-difluoro-ethanols is described in this paper.
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