SN2 Reactions of a Carbon Nucleophile with N-Aryl-O-pivaloylhydroxylamines: A Model for in Vivo Reactions of Carcinogenic Metabolites of Aromatic Amines

DOI: 10.1021/jo00284a012

Source and publish data:

Journal of Organic Chemistry p. 5430 - 5431 (1989)

Update date:2022-07-30

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Authors:

Novak, Michael

Martin, Kristy A.

Heinrich, Julie L.

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Article abstract of DOI:10.1021/jo00284a012

The reaction of the N-aryl-O-pivaloylhydroxylamines 3a-c with N,N-dimethylaniline 4 to generate the diphenylamines 5a-c and 6a-c, a model for the in vivo reaction of similar esters of carcinogenic N-arylhydroxylamines with C-8 of quanosine, proceeds via a

Full text of DOI:10.1021/jo00284a012

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