Asymmetric alkylations of a phenylalanylglycinate equivalent. Novel route to dipeptides bearing α-alkyl-α-amino acid residues

Article abstract of DOI:10.1021/ja00158a041

Asymmetric single and double alkylations of chiral β-lactam acetate 1, which is a chiral glycinate as well as a phenylalanylglycinate equivalent, are studied. First, the sequential asymmetric double alkylation of 1a is performed to give the corresponding