An approach to carbapenems from α,β-unsaturated sugar lactones

Article abstract of DOI:10.1016/S0040-4020(01)88341-1

Conjugate addition-rearrangement of N-substituted hydroxylamines to α,β-unsaturated D-lactones provides a short and effective route to 3-substituted isoxazolidin-5-ones. These compounds were converted into 4-substituted azetidin-2-ones via a two-step proc