New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-disubstituted-1-pyrrolidinyl)quinoline-3-carboxylic acids

DOI: 10.1021/jm00164a060

Source and publish data:

Journal of Medicinal Chemistry p. 849 - 854 (1990)

Update date:2022-09-26

Topics:

Authors:

Hagen Hagen

Domagala

Heifetz Heifetz

Sanchez Sanchez

Solomon Solomon

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Article abstract of DOI:10.1021/jm00164a060

A series of 7-(3-amino- or 3-aminomethyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro- 4-oxo-3-quinolinecarboxylic acids was synthesized and tested for antibacterial activity. Unique to these quinolones was the presence of a methyl or phenyl gro

Full text of DOI:10.1021/jm00164a060

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