Pyridinyl aminohydantoins as small molecule BACE1 inhibitors

DOI: 10.1016/j.bmcl.2010.01.136

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2326 - 2329 (2010)

Update date:2022-08-05

Topics:

Authors:

Zhou, Ping

Li, Yanfang

Fan, Yi Fan, Yi

Wang, Zheng

Chopra, Rajiv

Olland, Andrea

Hu, Yun Hu, Yun

Magolda, Ronald L.

Pangalos, Menelas

Reinhart, Peter H.

Turner, M. James

Bard, Jonathan

Malamas, Michael S.

Robichaud, Albert J.

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Article abstract of DOI:10.1016/j.bmcl.2010.01.136

A novel class of pyridinyl aminohydantoins was designed and prepared as highly potent BACE1 inhibitors. Compound (S)-4g showed excellent potency with IC₅₀ of 20 nM for BACE1. X-ray crystallography indicated that the interaction between pyridine

Full text of DOI:10.1016/j.bmcl.2010.01.136

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