CYTOCHALASAN SYNTHESIS: SYNTHESIS OF (17S,18S)-17,18-DIHYDROXY-10-(PROP-2-YL)-14-METHYL-CYTOCHALASA-6(7),13Z,19E-TRIENE-1,21-DIONE; AN ISOMER OF ASPOCHALASIN C

Article abstract of DOI:10.1016/S0040-4020(01)83439-6

On heating a dilute solution of a 2:1 mixture of the (8'E)- and (8'Z)-3-(1-oxotrienyl)-Δ³-pyrrolin-2-ones (36), Diels Alder cyclization occured.The minor (8'Z)-pyrrolinone cyclized stereoselectively to give the endo adduct (39) which has the as