Synthesis and in vitro activity of 4′ and 5′-modified analogues of apiosyl nucleosides as potent anti-HCV agents

DOI: 10.1080/15257770903396725

Source and publish data:

Nucleosides, nucleotides and nucleic acids p. 1104 - 1116 (2009)

Update date:2022-07-29

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Authors:

Li, Hua Li, Hua

Lee, Wonjae

Hong, Joon Hee

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Article abstract of DOI:10.1080/15257770903396725

Novel doubly branched apio dideoxynucleosides were synthesized starting from 1,3-dihydroxyacetone using an ozonolysis and Grignard addition as key steps, and evaluated for anti-hepatitis C virus (HCV) activity. The adenine derivative 24 showed significant

Full text of DOI:10.1080/15257770903396725

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