Novel 1′,1′-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist

DOI: 10.1021/jm100641g

Source and publish data:

Journal of Medicinal Chemistry p. 6996 - 7010 (2010)

Update date:2022-08-03

Topics:

Authors:

Nikas, Spyros P.

Alapafuja, Shakiru O.

Papanastasiou, Ioannis

Paronis, Carol A.

Shukla, Vidyanand G.

Papahatjis, Demetris P.

Bowman, Anna L.

Halikhedkar, Aneetha

Han, Xiuwen

Makriyannis, Alexandros

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Article abstract of DOI:10.1021/jm100641g

In pursuit of a more detailed understanding of the structural requirements for the key side chain cannabinoid pharmacophore, we have extended our SAR to cover a variety of conformationally modified side chains within the 9-keto and 9-hydroxyl tricyclic st

Full text of DOI:10.1021/jm100641g

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